移形上皮与鳞状上皮来源的恶性肿瘤摄取^(18)F-FDG差异性的实验研究

Differential Uptake of ^(18)F-FDG in Transitional Epithelium and Squamous Epithelium-derived Malignant Tumors

[目的]探讨来自不同上皮来源的肿瘤组织葡萄糖代谢的差异,为临床PET/CT应用中如何判断上皮组织来源的恶性肿瘤葡萄糖摄取出现的假阳性和假阴性等问题提供理论依据。[方法]BALB/C裸鼠12只,随机分为2组,并且皮下分别接种膀胱癌EJ细胞和宫颈癌Hela细胞,1×106/0.2ml使其成瘤。行小动物PET扫描,取得葡萄糖标准化摄取值(SUV),测量SUVmax和SUVmean对肿瘤组织葡萄糖代谢进行评价。[结果]膀胱癌SUVmax:4.22±0.39,SUVmean:2.60±0.43;宫颈癌SUVmax:6.18±0.23,SUVmean:2.40±0.57。膀胱癌与宫颈癌的SUVmax值差异有统计学意义(t=-9.474,P<0.01),而SUVmean值无统计学差异。[结论]鳞状上皮来源的肿瘤葡萄糖摄取要高于移形上皮来源的。

[Purpose] To compare the difference of glucose metabolism of tumor tissue from two different epithelial origins,and to provide a theoretical basis for resolving false positive and false negative problem in PET/CT application.[Methods] Twelve BALB/C nude mice were randomly divided into two groups,subcutaneously inoculated with 1×10 6 /0.2ml of cervical cancer Hela cells and bladder cancer EJ cells respectively.Micro-PET was undertaken to obtain glucose standardized uptake values（SUV）.SUV max and SUV mean were measured to assess glucose metabolism in tumor tissues.[Results] SUV max and SUV mean for cervical cancer were 6.18±0.23 and 2.40±0.57,respectively.SUV max and SUV mean for bladder cancer were 4.22 ±0.39 and 2.60 ±0.43,respectively.SUV max between bladder cancer and cervical cancer was statistically different（t=-9.474,P0.01）,while SUV mean was not significantly different between them.[Conclusion] Squamous epithelium-derived malignant tumor such as cervical cancer has higher glucose metabolism than transitional epithelium-derived malignant tumor such as bladder cancer.