慢性阻塞性肺疾病急性加重期患者检测AT-Ⅲ的意义

Significance of Analysis AT-Ⅲ in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的探讨慢性阻塞性肺疾病（COPD）急性加重期患者检测抗凝血酶-Ⅲ（AT-Ⅲ）的意义。方法选取COPD急性加重期患者80例，cOPD急性缓解期患者75例，以及100例健康人群。PT和TT检测采用全自动血凝仪，FDP检测采用ELISA法，AT-Ⅲ采用免疫浊度法测定。结果对照组和COPD各分期组间的PT和TT指标差异无统计学显著性意义（P〉0．05），COPD急性加重期患者的FDP水平与缓解期患者相比差异无统计学显著性意义（P〉0．05）。而两组AT-Ⅲ水平比较差异有统计学显著性意义（P〈0．05）。结论AT-Ⅲ可作为COPD急性加重期患者凝血功能是否异常的常规检测指标之一。

Objective To discuss the significant of analysis AT-Ⅲ in acute exacerbation of chronic obstructive pulmonary dis- ease（COPD）. Methods Serum PT and TT of 80 patients with acute exacerbation of COPD,75 patients with acute remission of COPD and 100 healthy controls were determined PT and TT by hematopexis equipment,FDP was measured by ELISA, AT- Ⅲ by immunoblot assay. Results Patients with acute exacerbation or acute remission of COPD had higher level of FDP, lower level of AT-Ⅲ, than heaithy controls （P〈0. 05）,but TT and PT had no difference（P〉0.05）. The difference of AT-Ⅲwas significant between patients with acute exacerbation of COPD and patients with acute remission of COPD （P 0. 05） ,however FDP had no difference（P〉0. 05）. Conclusion AT-Ⅲ may be a useful factor for diagnosis hematopexis dis- order in acute exacerbation of chronic obstructive pulmonary disease.