四虫通络胶囊对慢性脑供血不足患者血栓前状态的干预研究

Effect of Sichong Tongluo Capsule on Prethrombotic State in Chronic Cerebral Circulation Insufficiency

目的观察四虫通络胶囊对慢性脑供血不足患者血栓前状态的干预效果。方法将320例气虚血瘀型慢性脑供血不足患者随机分为治疗组和对照组,各160例,对照组采用常规治疗,治疗组在常规治疗的基础上给予四虫通络胶囊口服,疗程为2个月。检测治疗前后血清一氧化氮(NO)、内皮素-1(ET-1)、纤维蛋白原(FIB)、组织型纤溶酶原激活物抑制物(PAI-1)和组织纤溶酶原激活物(t-PA)含量,并进行统计学处理。结果治疗组治疗后NO、t-PA上升,ET-1、FIB、PAI-1下降,差异有统计学意义(P<0.01),与对照组治疗后比较差异有统计学意义(P<0.01)。结论四虫通络胶囊能有效干预气虚血瘀型慢性脑供血不足患者血栓前状态。

Objective To investigate the effects of Sichong Tongluo capsule（STC） on prethrombotic state in patients（pts） with chronic cerebral circulation insufficiency（CCCI）.Methods Three hundreds and five pts with CCCI and qi deficiency and blood stasis syndrome were randomly divided into two groups：Control group（n=153） treated by routine treatment and treatment group（n=152） treated by STC based on the routine treatment for 2 months.The levels of serum nitric oxide（NO）,endothelin-1（ET-1）,fibrinogen（FIB）,plasminogen activator inhibitor-1（PAI-1）,and tissue-type plasminogen activator（t-PA） in were tested pre-and post-treatment.Results Compared with control group,the levels of serum NO and t-PA were increased,and ET-1,FIB,PAI-1 levels were decreased in treatment group（P0.01）.Conclusion STC could effectively intervent the prethrombotic state in pts with CCCI.