替硝唑联合维生素C对牙周炎大鼠血清IgG_1和IgG_(2a)的影响

Effect of tinidazole combined with vitamin C on serum IgG_1 and IgG_(2a) of periodontitis rats

目的探讨替硝唑联合维生素C对牙周炎大鼠的治疗作用及对血清IgG1和IgG2a的影响。方法给予牙周炎大鼠替硝唑联合维生素C处理(研究组),并与单纯给予维生素作对照,分析处理后不同时间点的牙龈指数(gingivalindex,GI)、牙周附着丧失(attachment loss,AL)及血清IgG1和IgG2a水平。结果①除2周的GI和AL外,两组治疗后各观察点的指标均优于治疗前;②研究组4周、6周和8周的AL和IgG2a水平低于对照组;③研究组6周和8周的GI低于对照组,IgG1水平高于对照组。结论联合治疗对牙周炎症状的改善效果优于单纯处理,并能纠正紊乱的IgG1和IgG2a水平。

Objective To explore the improvement effects of tinidazole combined with vitamin C on rats with periodontitis and the effects on serum IgG1 and IgG2a. Methods The rats with periodontitis were treated by combination therapy of tinidazole and vitamin C （research group）, while the control group was treated only with vitamin C. The following items at different treat time point were analyzed such as gingival index, attachment loss, serum IgG1 and IgG2a levels. Results ①Ex- cept the GI and AL at 2nd week, the other items at different time points of two groups were better than the condition be- fore treatment; ②AL and IgG2a level at 4th, 6th and 8th week after treatment of research group were lower than control group; ③GI level at 6th and 8th week of research group were lower than control group, while the IgG2a were higher than control group. Conclusion The combination therapy of tinidazole and vitamin C show a better improvement effect than the pure vitamin C treatment with a possible mechanism to correct disorders of the IgG1 and IgG2a levels.