舍尼亭联合α受体阻滞剂对逼尿肌过度活动患者尿动力学的影响

Effect of Tolterodine combined with α-blocker for urodynamic in patients of detrusor overactivity

目的探讨舍尼亭联合α受体阻滞剂治疗良性前列腺增生伴逼尿肌过度活动尿动力学的影响及疗效。方法 108例良性前列腺增生伴逼尿肌过度活动患者随机分为观察组和对照组,各54例,分别给予舍尼亭联合可多华和可多华单用治疗。结果治疗前两组Qmax、Pdet、VV、PVR、24 h排尿次数之间差异无统计学意义(P>0.05),治疗后两组Pdet、PVR、24 h排尿次数均较治疗前显著降低,VV则显著升高(P均<0.05),Qmax与治疗前差异无统计学意义(P>0.05),两组各指标之间差异有统计学意义(P<0.05)。治疗后均显著下降,观察组均显著低于对照组(P<0.05),观察组6例(11.11%)、对照组5例(9.26%)出现轻度不良反应,两组差异无统计学意义。结论舍尼亭联合α受体阻滞剂能有效改善尿动力学,缓解良性前列腺增生患者的逼尿肌过度活动,安全有效。

Objective To investigate the effect of Tolterodine combined with α-blocker for urodynamic of benign prostatic hyperplasia associated with detrusor overactivity in patients. Methods All of 108 eases of benign prostatic hyperplasia as- sociated with detrusor overactivity were randomly divided into observation group and control group （n = 54）,and were giv- en round tolterodine combined with a-blocker and oL-blocker alone treatment. Results No significant difference of Pdet, VV and PVR,24 h urination between the Qmax two groups before treatment （P 〉 0.05）.After treatment,Pdet,PVR,24 h urination of the two groups were significantly reduced,while the VV were significantly increased（P 〈 0.05）, Qmax before and after treatment difference were not statistically significant（P 〉 0.05 ）,indicators the difference between two groups were statisti eally significant（P 〈 0.05）. The indicators of observation group were significantly lower than the control group （P 〈 0.05）. Six cases（11.11%）of observation group,5 cases （9.26%）of control group had mild adverse reactions,the difference were not statistically significant. Conclusion Tolterodine combined with α-blocker could effectively improve the urodynamic allevi- ate benign prostatic hyperplasia in patients with detrusor overactivity.