雷贝拉唑、左氧氟沙星及阿莫西林三联疗法治疗消化性溃疡的疗效观察

Clinical observation of rabeprazole,levofloxacin and amoxicillin triple therapy on peptic ulcer

目的观察雷贝拉唑、左氧氟沙星及阿莫西林三联疗法治疗消化性溃疡的疗效和安全性。方法选择2011年6月～2012年1月我院确诊的消化性溃疡患者120例作为观察对象,全部患者根据随机数字表法分为观察组(雷贝拉唑、左氧氟沙星及阿莫西林三联疗法)和对照组(奥美拉唑、克拉霉素及阿莫西林三联疗法)各60例,比较两组的临床疗效及Hp根除率。结果全部患者均顺利完成整个治疗过程,对照组治疗后的总有效率为78.3%,明显低于观察组的总有效率96.6%,差异有统计学意义(χ2=7.824,P=0.003 16)。观察组Hp根除率为93.3%(56/60),对照组Hp根除率为70.0%(42/60),两组比较差异有统计学意义(P<0.05)。结论雷贝拉唑、左氧氟沙星及阿莫西林三联疗法治疗消化性溃疡疗效显著,能明显根除幽门螺杆菌,安全性好,值得推广和应用。

Objective To explore the efficacy and security of rabeprazole, levofloxacin and amoxicillin triple therapy in the treatment of peptic ulcer. Methods Selected 120 cases peptic ulcer patients diagnosed in our hospital from June 2011 to January 2012 as the observation objects, all patients according to the random number table were divided into treatment group （rabeprazole, levofloxacin and amoxieillin triple therapy） and control group （omeprazole, clarithromycin and amoxicillin triple therapy） with 60 cases, and the clinical efficacy of Hp eradication rate of two groups were compared. Results All patients successfully completed the entire course of treatment, the total effective rate of the control group was 78.3%, was significant- ly lower than the treatment group （96.6%）, and the difference was statistically significant （χ2= 7.824, P = 0.003 16）. Hp eradi- cation rate of the observation group was 93.3% （56/60）, Hp eradication rate of control group was 70.0% （42/60）, and the difference was statistically significant （P 〈 0.05）. Conclusion Rabeprazole, levofloxacin and amoxicillin triple therapy in the treatment of peptic ulcer is a significant eradication of Helicobacter pylori significantly, security, and worthy of promotion and application.