Galectin-3、CK19在桥本氏甲状腺炎中的表达及意义

Expression of Galectin-3、CK19 in hashimoto thyroiditis and its significance

目的分析桥本氏甲状腺炎(HT)中Galectin-3及CK19的表达情况,探讨Galectin-3、CK19在HT合并甲状腺乳头状癌(PTC)及HT伴不典型细胞群中的表达意义。方法复习我院存档的HT病例切片,选取18例伴不典型细胞群的HT、18例伴PTC的HT,以20例单纯桥本氏甲状腺炎的病变组织做对照。行免疫组化单克隆抗体染色,一抗为Galectin-3和CK19,统计并分析。结果 Galectin-3在HT伴PTC、HT伴不典型细胞群及对照组的表达率分别为83%、11%、5%,第一组与后两组间差异有统计学意义(P<0.05),后两组间差异无统计学意义(P>0.05)。CK19在HT伴PTC、HT伴不典型细胞群及对照组的表达率分别为89%、78%、10%,前两组间差异无统计学意义(P>0.05),前两组与对照组间差异有统计学意义(P<0.05)。结论 HT增生淋巴组织周围常可见不典型细胞群,这些不典型细胞群有时与PTC难以区分,通过Galectin-3、CK19联合免疫组化染色有助于判断不典型细胞群的性质。

Objective To investigate the expression and clinical significance of Galectin-3, CK19 in Hashimoto Thyroiditis （HT） associated with papillary thyroid carcinoma（PTC） and HT with atypical cell groups. Methods By Immunohistochem- istry was used to detect 18 cases of HT associated with PTC and 18 cases of HT with atypical cell groups,compare them with 20 cases of simple HT as controls,and explored the positive expression of Galectin-3 ,CK19.Finally,analyzed the results. Results The expression rates of Galectin-3 in HT associated with PTC and HT with atypical cell groups and the controlled group were as follows： 83%, 11% ,5%. There has statistically significance between the first group and the latter two groups （P 〈 0.05） ,and no statistically significance between the latter two groups（P 〉 0.05）. The expression rates of CK19 in HT associated with PTC and HT with atypical cell groups and the controlled group were as follows：89% ,78%, 10%,there has statistically significance between the first two groups and the last group （P 〈 0.05）,and no statistically significance be- tween the first two groups（P 〉 0.05）. Conclusion Atypical cell groups were often seen around the lymphoid tissue of HT. These atypical cell groups are sometimes difficult to distinguish from PTC. We results suggest that Galectin-3 and CKI9 joint detection can help to judge the nature of the atypical cell groups.