坦索罗辛治疗输尿管下段结石并肾绞痛的疗效观察

Effect observation of tamsulosin in treatment of lithiasis in lower ureters with renal colic

目的探讨α1受体阻断药坦索罗辛对输尿管下段结石并肾绞痛的疗效。方法输尿管下段结石患者92例,分为两组。对照组46例,常规治疗:肾绞痛期抗生素防治感染+间苯三酚注射液80 mg静脉滴注,每天1次,同时每日饮水>2 000 mL;治疗组46例,常规治疗+口服坦索罗辛0.4 mg,qd,4周。结果对照组结石排出率52.27%,平均排出时间(13.21±6.32)d,治疗期间肾绞痛发作22次;60 min肾绞痛缓解有效率68.18%;治疗组结石排出率88.89%,平均排出时间(7.36±2.47)d,治疗期间肾绞痛发作6次;60 min肾绞痛缓解有效率84.44%,两组排出率比较差异有显著性(P<0.05)。结论坦索罗辛治疗输尿管下段结石能明显提高结石排出率、60 min肾绞痛缓解有效率,缩短排出时间,减少治疗期间肾绞痛的发作次数。

Objective To assess the effect of tamsuiosin （alpha 1 receptors blocker） in treatment of ureterolithiasis in the lower ureters with renal colic. Methods From January 2008 to October 2011,92 patients with ureterolithiasis in the lower ureters were randomly divided into two groups ：group A （n = 46） was subjected to our regular treatment （antibiotics and phloroglucinolon 80rag qd in zhe during renal colic）and group B （n = 46） was regular treatment combined with tamsulosin 0.4 rag, qd. Results In group A,52.27% of the patients expelledthe calculi and was lower than 88.89% in group B. The mean time discharged calculus in group A was more longer and attack times ofrenal eolicsmore frequent and 60min renal colic relief efficiency compared with group B [（13.21＋6.32） days vs （7.36＋2.47） days,22 times vs 6 times, 68.18% vs 84.44%,respectively]. Conclusion Tamsuiosin treatment of lower ureteral stones can significantly improve zhe stone ex- pulsion rate,60 min renal colic relief efficiency , shorten the discharge time,reduce the number of episodes of renal colic during treatment.