放、化疗与手术切除并一期修复组织缺损模式治疗躯干浅表恶性肿瘤临床研究

Clinical research on treatments including radiotherapy,chemotherapy,radical surgery to remove the tumor,and flap for tissue defect repair for the trunk superficial malignant tumor

目的探讨躯干浅表恶性肿瘤手术前、后辅助放、化疗,手术切除肿瘤并一期修复组织缺损的方法和疗效。方法回顾我院浅表恶性肿瘤病例,收集病历资料及随访资料,分为放化疗加手术组、单纯放化疗组和单纯手术组三组,比较三组的疗效。结果放化疗加手术组患者肿瘤切除缺损组织一期修复,移植皮瓣存活良好,生活质量明显提高,明显优异于其余两组(P<0.05)。结论选择术前大剂量放、化疗,手术根治性切除肿瘤同时行岛状皮瓣或游离组织瓣修复缺损组织,手术后常规放、化疗模式治疗躯干浅表恶性肿瘤效果理想,明显提高了患者的生活质量。

Objective To explore the method and effect of treatment of trunk superficial malignant tumor through surgical resection of the tumor and tissue defect repair at the first time, and auxiliary radiotherapy and chemotherapy before and af- ter operation. Methods Reviewed superficial malignant tumor cases,and collected medical records and tbllow-up data, which were divided into chemoradiation plus operation group, simple chemotherapy group and simple operation group. The curative effect were compared among the three groups. Results In the chemoradiation plus operation group, patients were accepted with that tumor resection and a defect repair of organization at the same time,and the transplanted skin flap sur- vived well. The quality of life of the group improved obviously and was better than that in the other two groups（P 〈 0.05）. Conclusion The treatment, that including high-dose preoperative radiotherapy and chemotherapy, radical surgery to remove the tumor,flap or free flap for tissue defect repair and routine post-operative radiotherapy and chemotherapy,for the trunk superficial malignant tumor was satisfactory, significantly improved the patients＂ quality of life.