T细胞亚群检测对传染性单核细胞增多症的临床意义

Clinical significance of T lymphocytes in infectious mononucleosis

目的探讨T细胞亚群检测对传染性单核细胞增多症(IM)的临床意义。方法采用流式细胞术检测IM患儿急性期、恢复期(更昔洛韦治疗后2周)、随访期(治疗后4周)以及正常对照组外周血淋巴细胞亚群,并对结果进行比较。结果 IM患儿急性期以及恢复期较对照组外周血中CD4+T细胞百分比、CD4+/CD8+比值均明显下降(P<0.05),CD8+T细胞百分比则明显升高(P<0.05)。恢复期(更昔洛韦治疗后2周)CD4+T细胞百分比、CD4+/CD8+比值较治疗前升高(P<0.05),而CD8+T细胞百分比则较治疗前降低(P<0.05),差异均有统计学意义。随访组与对照组比较,差异无统计学意义(P>0.05)。结论外周血T细胞亚群的检测对评估IM患儿的细胞免疫功能状况、辅助诊断和指导治疗具有临床意义。

Objective To study the clinical significance of T lymphocytes in children with infectious mononucleosis （IM）. Methods Used flow cytometric analysis to detect IM peripheral blood lymphocyte subtype of 42 patients and 39 cases in normal control group,and then compared with each other. Results Compared with control group, CD8＋ T cells increased significantly （P 〈 0.05）, CD4＋ cells reduced significantly, and CD4＋/CD8＋ cells ratio decreased obviously in acute stage and convalescence stage group （P 〈 0.05）. Compared with acute stage group, CD8~ T cells decreased significantly （P 〈 0.05）, CD4~ T cells and CD4＋/CD8＋ cells ratio increased obviously （P 〈 0.05） in convalescence stage group. The results of follow-up and control group had no obvious differences （P 〉 0.05）. Conclusion The variation of T lymphocytes can bring obvious clin- ical significance to IM patients for evaluation of cellular immune function condition, auxiliary diagnosis and guide therapy.