摘要
目的探讨细胞因子IL-6与IL-8在慢性阻塞性肺疾病(COPD)发病中的作用。方法采用放射免疫法分别检测60例COPD急性加重期患者(实验组)在常规治疗前后及60例健康成人(健康对照组)血清白细胞介素-6、白细胞介素-8及FEV1/FVC等指标。结果实验组血清IL-6、IL-8及FEV1/FVC在治疗前后差异均有统计学意义(P<0.05)。治疗后实验组与健康对照组比较IL-6无统计学意义(P>0.05),IL-8及FEV1/FVC有统计学意义(P<0.05)。结论 IL-6参与了急性期COPD气道炎症反应,IL-8参与了COPD的发生与发展全过程,IL-6、IL-8水平与肺功能之间存在相关性。
Objective To investigate the cytokine IL-6 and IL-8 in the pathogenesis of chronic obstructive pulmonary disease. Methods Examined separately serum interleukin-6, interleukin-8 and FEV1/FVC of the 60 cases with acute ex- acerbation of COPD in the conventional before and after therapy, and 60 healthy adult by radioimmunoassay. Results In the experimental group, significant difference in levels of serum IL-6, 1L-8 and FEV1/FVC before and after therapy （P 〈 0.05）. After treatment compared with the healthy control group, no significant difference in IL-6, but there were significant differ- ences in the IL-8 and FEV1/FVC. Conclusion IL-6 involved in the acute phase of COPD airway inflammation,lL-8 in- volved entirely in the occurrence of COPD and the development,IL-6 and IL-8 levels are relevant to lung function.
出处
《中国现代医生》
2012年第31期36-37,共2页
China Modern Doctor
基金
江西省南昌市2011年科技支撑计划项目(项目申报代码:洪科发广十[2011]字87号
项目编号:16号)
关键词
IL-6
IL-8
慢性阻塞性肺疾病
肺功能
Interleukin-6
Interleukin-8
Chronic obstructive pulmonary disease
Lung function
