摘要
目的探讨过敏性紫癜性肾炎患儿血清中的总IgE及嗜酸性阳离子蛋白(ECP)的变化及临床意义。方法 50例急性期过敏性紫癜患儿中无肾损害HSP组患儿26例,HSPN患儿共24例,另选同期来我院进行健康体检的30例健康儿童作为正常对照组,应用酶联免疫荧光法检测各组血清总IgE和ECP浓度的变化情况。结果①HSP急性期HSPN组的血清总IgE、ECP均分别明显高于无肾损害组及健康对照组(P<0.05或P<0.01),且无肾损害组的血清总IgE、ECP分别明显高于健康对照组(P<0.01)。②HSP恢复期HSPN组的血清总IgE、ECP均分别明显高于无肾损害组及健康对照组(P<0.05)。③HSP急性期血清ECP与血清IgE二者间呈明显正相关(r=0.68,P<0.05)。结论血清总IgE和ECP协同,均参与了过敏性紫癜及肾损害的发生、发展过程,可以作为临床诊断及判断HSP及HSPN病情进展程度的有效监测指标之一。
Objective To investigate the changes and clinical significance of serum total IgE and eosinophil cationic pro- tein （ECP） in allergic purpura nephritis. Methods Fifty cases of acute allergic purpura in children as an object of observa tion, kidney damage the HSP group of 26 patients, 24 patients with HSPN children, elect 30 healthy children of the same period came to our hospital health examination as a normal control group, the application of the enzyme-linked im munosorbent assay in serum total IgE and ECP concentration changes. Results （1）HSP acute phase HSPN group total serum IgE, ECP are, respectively, significantly higher than without renal impairment group and the healthy control group （/9 〈 0.05 or P 〈 0.01）, and no the serum total group of kidney damage IgE, ECP were significantly higher than the control group （P 〈 0.01）. （2）HSP convalescent HSPN group of serum total IgE, ECP, respectively, significantly higher than without renal impairment group and the healthy control group （P 〈 0.05）, but no group of kidney damage total serum IgE, ECP and healthy control group, the difference was not statistically significant （P 〉 0.05）. （3）The HSP acute phase of serum ECP and serum IgE between the two groups was a positive correlation （r = 0.68, P 〈 0.05）. Conclusion Serum total IgE and ECP synergies are involved in allergic purpura and renal damage occurred, the process of development, can be used as one of the effective monitoring indicators of clinical diagnosis and judgment HSP and HSPN progression extent.
出处
《中国现代医生》
2012年第31期44-45,共2页
China Modern Doctor
