外源性磷酸肌酸对难治性强迫症术后认知功能的疗效观察

Clinical observation of effects of exogenous phosphocreatine on short term cognitive function in patients with refractory obsessive compulsive disorder following stereotactic sugery

目的观察外源性磷酸肌酸对改善强迫症术后的认知功能及减少副作用的效果。方法将62例立体定向毁损术后的难治性强迫症患者随机分为治疗组和对照组,治疗组在常规治疗的基础上给予磷酸肌酸钠治疗。于术前及术后第1、7、30天分别采用简易智力状态量表(MMSE)、中国修订韦氏成人智力量表(WAIS-RC)和韦氏记忆量表(WMS)对治疗组和对照组患者的认知功能进行评定。分别观察两组术后的副作用的发生情况。结果难治性强迫症患者立体定向内囊前肢毁损术后有一定的认知功能障碍,在磷酸肌酸治疗组认知功能于术后1周就恢复正常,而对照组1个月后才恢复正常。治疗组的两便失禁等副作用发生率明显低于对照组(P<0.05)。结论外源性磷酸肌酸可促进难治性强迫症患者立体定向内囊前肢毁损术后的认知功能的恢复,减少副作用的发生。

Objective To observe the effect of exogenous phosphocreatine on short term cognitive function in patients with refractory obsessive compulsive disorder following stereotactic capsulotomy.Methods Sixty-two patients with refractory obsessive compulsive disorder were randomly divided into treated group and control group after anterior capsulotomy.The patients in treated group were given exogenous phosphocreatine besides conventional therapy.The efficacy was evaluated using by mini mental state examination（MMSE）,WAIS-RC and WMS before surgery and 1,7,30 days postoperation.Results Short-term cognitive function after stereotactic anterior capsulotomy was impaired.Short-term cognitive function returned to normal in 7 days in treated group,but one month in control group.The side effect was reduced significant in treated group（P 0.05）.Conclusion Exogenous phosphocreatine can accelerate the recovery of cognitive function in patients with refractory obsessive compulsive disorder following stereotactic capsulotomy and reduce the side effect of anterior capsulotomy.