冠状动脉慢血流现象影响因素研究

Influence factors on coronary slow flow phenomenon

目的探讨冠状动脉慢血流现象的影响因素。方法行冠状动脉造影检查提示冠状动脉无明显狭窄患者340例,根据校正TIMI血流计帧法分为冠状动脉慢血流组240例和血流正常组100例。结果单因素分析显示冠状动脉慢血流组男性、吸烟率、体质量指数、红细胞压积、血清肌酐、尿酸和三酰甘油水平高于血流正常组,年龄和高密度脂蛋白胆固醇水平低于血流正常组(P<0.05);多因素Logistic回归分析显示,吸烟(OR=1.863,95%CI:1.069～3.245,P<0.05)和红细胞压积(OR=1.169,95%CI:1.083～1.261,P<0.01)是冠状动脉慢血流的独立危险因素。结论吸烟和红细胞压积增高可促进冠状动脉慢血流现象的发生。

Objective To analyze the influence factors on coronary slow flow phenomenon （CSFP）. Methods A total of 340 cases diagnosed by coronary angiography were divided into the CSFP group （n=240） and the normal coronary flow group （n= 100） according to the corrected TIMI frame count （CTFC）. Results Single factor analysis showed that CSFP group had higher proportions of male, smoking ratio, body mass index, hematocrit level, serum creatinine level, serum uric acid level and triacylglycerol level, and had lower age and high density lipoprotein-cholesterol level in comparison with normal coronary flow group （P^0.05）. Multivariate logistic regression analysis showed that smoking ratio （OR：I. 863, 95%CI..1. 069 to 3. 245,P〈0. 05） and hematocrit （OR： 1. 169, 95%CI： 1. 083 to 1： 261,P〈0.05） were the independent risk factors of the CSFP. Conclusion Smoking and high level of hematocrit might be involved in the pathogenesis of CSFP.