血清谷氨酰转肽酶和丙氨酸氨基转移酶水平与代谢综合征的关系研究

Association analyses of metabolic syndrome and the serum gamma glutamyltransferase or alanineaminotransferase

目的探讨北京地区体检人群谷氨酰转肽酶和丙氨酸氨基转移酶与代谢综合征的关系以及谷氨酰转肽酶和丙氨酸氨基转移酶是否可作为代谢综合征的组成成分。方法应用北京地区企事业单位人群2008年体检数据分析谷氨酰转肽酶和丙氨酸氨基转移酶与代谢综合征的相关性。代谢综合征诊断标准采用中国糖尿病学会（2004）标准。结果谷氨酰转肽酶和丙氨酸氨基转移酶高四分位组代谢综合征的检出率明显高于低四分位组。其中，男性谷氨酰转肽酶低四分位代谢综合征检出率为7．57％，高四分位代谢综合征检出率．为29．04％；女性谷氨酰转肽酶低四分位代谢综合征检出率为1．28％，高四分位代谢综合征检出率为17．86％；男性丙氨酸氨基转移酶低四分位代谢综合征检出率为9．27％，高四分位代谢综合征检出率为21．88％；女性丙氨酸氨基转移酶低四分位代谢综合征检出率为3．52％，高四分位代谢综合征检出率为14．70％（P〈0．01）。谷氨酰转肽酶诊断代谢综合征适宜的切点值是男性31U／L，女性18U／L。丙氨酸氨基转移酶诊断代谢综合征适宜的切点值是男性23U／L，女性19U／L。结论北京地区人群代谢综合征的检出率随着血谷氨酰转肽酶和丙氨酸氨基转移酶水平升高而升高，谷氨酰转肽酶和丙氨酸氨基转移酶水平在正常范围内时也符合这个规律。

Objective To explore the direct association between metabolic syndrome （MS） and gamma glutamyhransferase （GGT） or alanine aminotransferase （ALT） in Beijing men and women. Methods We investigated the medical check-up data from the 14,204 physical examination population （male 9524, female 4680） of year 2008. A cross-sectional study was carried out to explore the direct association between MS and GGT or ALT. MS was defined by the Chinese Diabetes Society （2004）. Chisquare test was performed to analyze the categorical variables. The receiver operating characteristic curve （ROC） was plotted to obtain area under curve （AUC） and the cutoff point of GGT and ALT. Results The prevalence of MS was signifi- cantly higher in subjects with the highest quartile of GGT or ALT than the subjects with the lowest quartile of GGT or ALT. For male, the prevalence of MS is 7.57% in the lowest GGT quartile and 29. 04% in the high- est GGT quartile. For female, the prevalence of MS is 1.28% in the lowest GGT quartile and 17. 86% in the highest GGT quartile. For male, the prevalence of MS is 9.27% in the lowest ALT quartile and 21.88% in the highest ALT quartile. For female, the prevalence of MS is 3. 52% in the lowest ALT quartile and 14. 70% in the highest ALT quartile （ P 〈0. 01）. The optimal cutoff points of GGT to diagnose MS were 31 U/L in men and 18 U/L in women. The optimal cutoff points of ALT to diagnose MS were 23 U/L in men and 19 U/ L in women. Conclusions The prevalence of MS increases with the increase in serum levels of GGT or ALT even through the normal range of GGT or ALT in Chinese men and women.