^(99)Tc^m-硫化铼胶体在乳腺癌前哨淋巴结活检中的应用

Application of ^(99)TC^m-colloidal rhenium sulfide in sentinel lymph node biopsy of breast cancer

目的:探讨99Tcm-硫化铼胶体在乳腺癌前哨淋巴结(SLN)活检中的应用价值。方法:30例T1～T2期乳腺恶性肿瘤患者入选,术前15～24 h乳晕下注射99Tcm-硫化铼,使用SPECT/CT进行SLN淋巴显像,定位;术中用γ探测仪寻找SLN,行SLN活检后,常规行乳癌手术;术后对SLN活检和腋窝淋巴结(ALN)清扫的病理结果进行比较分析。结果:30例共有29例检到SLN,共检出SLN 31枚,检出率,准确率分别为97.67%,100%;SLN状态与腋淋巴结转移的符合率为100%,无假阳性及假阴性情况出现。结论:99Tcm-硫化铼用于乳腺癌SLN活检是一种较理想的核素示踪剂。

Objective： To investigate the clinical application value of 99^Tc^m-colloidal rhenium sulfide in sentinel lymph nodes （SLNs） biopsy in patients with breast cancer. Methods： Thirty patients with T1-T2 breast cancer were enrolled. Patients were injected with 99^Tc^m-colloidal rhenium sulfide under the areola 15-24 h before operation, and lymphoscintigraphy and mapping of the SLNs was subsequently performed with SPECT/CT. Gamma probe-guided SLNs detection and biopsy was employed during surgery before the breast cancer resection. The results of SLN biopsy and histological examination were compared and analyzed after surgery. Results： SLNs were detected in 29 of the 30 patients and a total of 31 SLNs were identified. The detection rate and accuracy rate was 97.67% and 100%, respectively. The coincidence rate of the SLNs status and axillary lymph node metastasis was 100%, and no false positive or negative detections occurred. Conclusion： 99^Tc^m-colloidal rhenium sulfide is an ideal tracer for SLNs biopsy in patients with breast cancer.