镁及镁合金植入体在骨科临床中的应用与进展

Progress of magnesium ions and magnesium alloy implant application in the clinical orthopaedics

背景:镁是可被人体吸收的常量元素,作为医用生物材料具有明显的优势。目的:综述镁及镁合金在骨科应用中的优点、缺点及近年来国内外的研究进展。方法:由第一作者检索2000/2011PubMed数据及CNKI数据库有关镁离子合金在医疗领域的研究进展等方面的文献。结果与结论:传统医用金属材料包括不锈钢、钴基合金和钛基合金存在生物相容性差、生物力学性能不匹配、需要二次手术等弊端,镁合金具有良好的生物力学相容性、可降解性能、生物安全性,并且资源丰富。可在生理电解质环境中通过腐蚀而发生降解的特性,在骨科领域展示了巨大的潜在应用前景。

BACKGROUND： Magnesium ions are constant element, can be absorbed by the body and have obvious advantages as medical biomaterials. OBJECTIVE： To summarize the advantages, disadvantages, and research progress of magnesium ions and magnesium alloys application in orthopedics in recent years. METHODS： PubMed database and CNKI database were used to search the articles published from 2000 to 2011 on the progress of magnesium ions and magnesium alloys application in medical field. RESULTS AND CONCLUSION： The traditional medical metal materials including stainless steel, cobalt-based alloy and titanium based alloys which have the disadvantages of poor biocompatibility, un-matched biomechanical properties and the second surgery, and other defects. Magnesium alloys have good biomechanical compatibility, biodegradable performance, bio-security and rich resource. Magnesium alloys have the characteristics of degradation through the corrosion under physiological electrolyte environment and show a great application potential in the orthopedics field.