递增负荷运动对大鼠抑郁症模型行为学功能及孤啡肽水平的影响

Effects of progressive load exercise on ethology and orphanin levels in depression rat model

目的探讨运动在治疗抑郁症中的治疗价值及可能机制。方法应用慢性中等强度应激复制大鼠抑郁症模型。实验动物随机分为正常组、模型组、氟西汀组和运动组。应用Open-Field法测定各组行为学指标,ELISA法测定血浆和下丘脑孤啡肽水平。结果用药或运动后2周,实验动物行为学功能改善。与模型组比较,氟西汀组及运动组下丘脑及外周血孤啡肽水平显著降低,差异有统计学意义(均为P<0.05)。氟西汀组及运动组比较,下丘脑及外周血孤啡肽水平差异无统计学意义。结论运动疗法疗效与氟西汀类似,对抑郁症有显著的改善效果,可根据情况选择使用。

Objective To explore the therapeutic value and possible mechanism of motion on treating depression. Methods De- pression rat model was introduced by applying chronic stress with medium intensity. The experimental animals were randomly di- vided into normal group,model group,fluoxetine group and motion group. Open-Field method was used to examine ethologic param- eters in different groups;ELISA was applied to measuring orphanin levels in plasma and hypothalamus. Results After two weeks＇ treatment of medication or motion,ethologic function was improved in the experimental animals. As compared with those in model group,the orphanin levels in plasma and hypothalamus were significantly lower,and the differences were statistically significant（all P〈0.05）. There was no significant difference in orphanin level in plasma and hypothalamus between fluoxetine group and motion group. Conclusion The therapeutic effect is similar between fluoxetine group and motion group. Motion therapy has pronounced effect on depression,and can be used as a choice for treatment.