皮瓣移植及免疫调节

Flap transplantation and immunoregulation

背景:皮肤损伤非常常见,皮瓣移植是治疗皮肤损伤的方法之一,而且已被广泛应用。设计合理的皮瓣移植,抑制移植后排斥反应,可以改善移植皮瓣的存活状态。目的:研究皮瓣移植后的免疫调节机制及抑制调节因素,为皮瓣移植的免疫调节研究提供参考信息。方法:检索万方数据库2002至2011年收录皮瓣移植后免疫调节相关研究文献,并进行深入分析,对皮瓣移植动物模型建立可行性的实验研究和一氧化氮、成纤维细胞生长因子、表皮生长因子对皮瓣移植的影响以及皮瓣移植后的微循环保护研究和感觉神经末梢再生研究进行实验数据分析,以明确影响移植皮瓣存活的因素,并进行调控,延长移植皮瓣的存活期,改善皮瓣移植后的存活状态。结果与结论:皮瓣移植的大鼠实验模型是一种很好的皮瓣移植动物模型,可以进行各种移植皮瓣的模型建立,并且可以用于皮瓣移植免疫以及微循环等各方面的实验研究。在皮瓣移植后的免疫调节中,一氧化氮和成纤维细胞生长因子以及表皮生长因子均可以对免疫反应进行调控影响,而异丙酚以及盐酸罂粟碱等物质可以对皮瓣移植后的微循环保护起到一定的作用。

BACKGROUND： Skin lesions are very common, and flap transplantation is a kind of treatment method for skin lesions, and has been widely applied. Design reasonable flap transplantation and suppress the rejection after transplantation can improve the survival status of the transplanted flap. OBJECTIVE： To research the immunoregulation mechanism and inhibitory factor after flap transplantation, and to provide reference information for the research of immunoregulation after flap transplantation. METHODS： The Wanfang database was searched for the related articles on the immunoregulation after flap transplantation from 2002 to 2011 and the in-depth analysis was performed. The experimental data analysis was performed to analyze the feasibility of the establishment of flap transplantation models, the effect of nitric oxide and flbroblast growth factor on flap transplantation, as well as the microcirculation protection after flap transplantation, in order to indentify the influential factors of the survival of transplanted flap, and to regulate, extend the survival of the transplanted flap and improve the state of survival after flap transplantation. RESULTS AND CONCLUSION： The rat model with flap transplantation is a good flap transplantation animal model, it can be used to establish the model with various flap transplantation, and can be used for the experimental research on the immunity and the microcirculation of flap transplantation. During the immunoregulation after flap transplantation, both nitric oxide and fibroblast growth factor has regulation effect on the immune response, while the propofol and papaverine hydrochloride substances play a important role in microcirculation protection after flap transplantation.