Eph受体在卵巢癌中的研究进展

Progress of Eph in ovarian cancer

促红细胞生成素肝细胞(erythropoietin-producing hepatocellular,Eph)受体是酪氨酸受体家族中的一员,广泛表达于人类多种组织或细胞中,具有调节细胞生长、迁移及血管形成的潜在作用。近年来研究发现,EphA2、EphB2、EphB4在卵巢癌中呈现高表达,这种高表达与肿瘤的增殖、转移、血管形成和侵袭性相关,与患者预后负相关,有可能成为卵巢癌患者的预后指标或治疗靶点。

Eph receptor, a member of the largest family of tyrosine kinase receptors, is widely expressed in various human tis- sues and capable of modulating cell proliferation, migration and angiogenesis. In recent years, EphA2, EphB2 and EphB4 have been found to be overexpressed in ovarian cancer, which is related to the proliferation, metastasis, angiogenesis and invasion of ovarian cancer and the survival of patients. It is suggested that Eph may be a prognostic indicator for the patients or a promising therapeutic tar- get for ovarian cancer.