期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

basal-like乳腺癌临床病理学特点分析

下载PDF
导出
摘要 目的探讨乳腺癌的分子学及免疫组织化学分型及基底细胞样(basal-like)乳腺癌的临床病理学特征。方法针对2000年1月至2010年12月于我院外科行乳腺癌根治疗性手术或乳腺癌保乳手术切除的标本中选出"三阴性"乳腺癌(ER阴性、PR阴性、HER2阴性)50例,采用ER、PR、HER2、CK5/6和EGFR组合免疫组织化学结果定义BLBC(ER-、PR-、HER2-、CK5/6+和/或EGFR+)和非BLBC(ER-、PR-、HER2-、CK5/6-和EGFR-)2个亚型。观察两组的临床及病理学特征。结果肿瘤大小、年龄、淋巴结是否转移、组织学类型、组织学分级、临床分期和局部复发情况在二种亚型中差异均无统计学意义,而月经状态、Ki-67及淋巴管浸润情况在各亚型中差异具有统计学意义。BLBC型乳腺癌绝经前比例较高,而Ki-67比率及淋巴管浸润亦均高于非BLBC型乳腺癌(P=0.009及P=0.008)。结论本组研究显示,在三阴性乳腺癌当中,与非BLBC比较,BLBC多发生于绝经后妇女,预后较差。
作者 郑玉军 张忠鲁
机构地区 大连市友谊医院肿瘤科
出处 《中国老年保健医学》 2012年第5期21-23,共3页 Chinese Journal of Geriatric Care
关键词 乳腺肿瘤 基底细胞 病理学 局部复发 预后
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献16

  • 1Ellis IO, Schnitt SJ, Sastre-Garau X, et al. Invasive breast carcinoma/ Tavassoli FA, Devilee P. World Health Organization classification of tumors. Pathology and genetics of tumors of the breast and femal genital organs[ J]. Lyon : IARC Press,2003 : 13 - 59.
  • 2皋岚湘,杨光之,丁华野,李琳.基底细胞样型浸润性乳腺癌病理形态观察[J].中华病理学杂志,2008,37(2):83-87. 被引量：36
  • 3Nielsen TO, Hsu FD, Jensen K, et al. Immunohistoehemical and clini- cal characterization of the basal-like subtype of invasive breast carcino- ma[ J ]. Clin Cancer Res,2004,10 ( 16 ) :5367 - 5374.
  • 4Livasy CY, Karaca G, Nanda R, et al. Phenotypie evaluation of the bas- al-like subtype of invasive breast carcinoma[ J]. Mod Pathol,2006,19 (2) :264 -271.
  • 5Dent R,Trudeau M, Pritehard KI,et al. Triple-negative breast cancer: clinical features and patterns of recurrence [ J . Clin Cancer Res, 2007,13 ( 15 pt 1 ) :4429 - 4434.
  • 6Nguyen PL,Taghian AG, Katz MS, et al. Breast Cancer Subtype ap- proximated by estrogen receptor, progesterone receptor, and HER- 2 is associated with local and distant recurrence after breast-conserving ther- apy[J]. J Clin Oncol,2008,26(14) :2373 -2378.
  • 7Kreike B, van Kouwenhove M, Horlings H, et al. Gene expression profi- ling and histopathological characterization of triple-negative/basal-like breast carcinomas[ J]. Breast Cancer Res,2007,9 (5) :R65.
  • 8Rakha EA, El-Sayed ME, Green AR, et al. Prognostic markers in triple. negative breast cancer[ J]. Cancer,2007,109( 1 ) :25 - 32.
  • 9Tischkowitz M, Brunet JS, Begin LR, et al. Use of immunohistochemical markers can refine prognosis in triple negative breast cancer[ J]. BMC Cancer, 2007,7 : 134.
  • 10Sasa M, Bando Y, Takahashi M, et al. Screening for hasa marker ex-pression is necessary for decision of therapeutic strategy for triple-neg- ative breast cancer[ J ]. J Surg 0ncol,2008,97 (1) :30 -34.

二级参考文献19

  • 1步宏,郑杰.美国临床肿瘤学会/美国病理学医师学院乳腺癌HER2检测指南简介[J].中华病理学杂志,2007,36(7):496-497. 被引量：24
  • 2Matos I, Dufloth R, Alvarenga M, et al. p63, cytokeratin 5, and P-cadherin : three molecular markers to distinguish basal phenotype in breast carcinomas. Virchows Arch, 2005, 447(4):688-694.
  • 3Finak G, Sadekova S, Pepin F, et al. Gene expression signatures of morphologically normal breast tissue identify basal-like tumors. Breast Cancer Res, 2006, 8(5) :R58.
  • 4Perou CM, Sφrlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature, 2000, 406(6797) :747-752.
  • 5Sφrlie T, Perou CM, Tibshirani R, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Nail Aead Sci U S A, 2001, 98(19) :10869-10874.
  • 6Sφrlie T, Tibshirani R, Parker J, et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Nail Acad Sci U S A, 2003, 100(14):8418-8423.
  • 7Sotiriou C, Neo SY, McShane LM, et al. Breast cancer classification and prognosis based on gene expression profiles from a population-based study. Proc Natl Acad Sci U S A, 2003,100(18):10393-10398.
  • 8Nielsen TO, Hsu FD, Jensen K, et al. Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin Cancer Res, 2004, 10(16) :5367-5374.
  • 9Fulford LG, Easton DF, Reis-Filho JS, et al. Specific morphological features predictive for the basal phenotype in grade 3 invasive ductal carcinoma of breast. Histopathology, 2006,49(1):22-34.
  • 10Reis-Filho JS, Milanezi F, Steele D, et al. Metaplastic breast carcinomas are basal-like tumours. Histopathology, 2006, 49(1):10-21.

共引文献35

中国老年保健医学
2012年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部