青年冠心病患者冠状动脉病变与血清尿酸的临床研究

Clinical Study on Coronary Artery Disease and Uric Acid Level in Serum in Young Patients with Coronary Heart Disease

目的:研究青年冠心病患者冠状动脉病变与血清尿酸(UA)的关系。方法:青年冠心病组(A组,≤45岁,75例)又分为单支(A1组,42例)、双支(A2组,16例)和3支或以上冠状动脉狭窄组(A3组,17例)及对照组64例。测定UA水平,分析冠状动脉病变程度与UA的关系,并从性别、既往病史、个人史、血生化指标等方面进行比较。结果:A2和A3组UA水平显著高于对照组(P<0.05)。男性冠心病患者明显多于女性(P<0.05)。冠心病的相关危险因素还有肥胖、高甘油三酯及高低密度脂蛋白胆固醇。结论:UA水平升高与冠心病病变严重程度密切相关,早期干预有可能预防青年心血管事件的发生。

Objeetive： To study the relationship between coronary artery disease and uric acid level in serun in young patients with coronary heart disease. Methods： One hundred and thirty nine young patients（ ≤45 years）were divided into coronary heart disease group（75 cases, subdivided into single-branch（A1, 42 cases）, double-branch（A2, 16 cases） and three-branch（A3, 17 cases）groups）and control group（64 cases）. The relationship between uric acid level in serum and coronary artery diseaes was analyzed. Sex, past medical history and biochemical indexes were compared. Results： The UA level in the A1 and A3 groups were significantly higher than that in control group（ P 〈 0.05）. Male patients were more than female patients（ P 〈 0.05）. Other risk factors included obesity, high riglycerides and low-density li- poprotein cholesterol. Conclusion： Increased uric acid level in serum is related with the severity coronary heart disease. Early intervention might prevent the cardiovascular events in youth.