抗精神病药对精神分裂症患者体质量、血糖的影响

Influence of Antipsychotics on Body Mass,Blood Glucose of Patients with Schizophrenia

目的:探讨4种抗精神病药物对精神分裂症患者体质量、血糖的影响。方法:住院精神分裂症患者分为奥氮平组(32例)、利培酮组(63例)、舒必利组(51例)和喹硫平组(21例),于治疗前、治疗后第4、8周分别称重,测血糖。结果:治疗4周后与治疗前比患者体质量无统计学意义,治疗8周后与治疗前比体质量增加(P<0.05);治疗后4及8周与治疗前比血糖无统计学意义。结论:4种抗精神病药物对精神分裂症患者急性期短期治疗的体质量有影响,而对血糖无明显影响。

Objective： To investigate the influence of the four antipsychotics on body mass, blood glucose of patients with schizophrenia. Methods： The patients with schizophrenic were divided into olanzapine（32 eases）, risperidone（63 eases）, sulpiride（51 cases）and quetiapine groups（21 eases）. The body mass and blood glucose were determined before treatment and 4 and 8 weeks after treatment. Results： The body mass of all the patients with schizophrenia had no significant difference after 4 weeks treatment compared with before treatment. The body mass of all the patients with schizophrenia was increased after 8 weeks treatment compared with before treatment（ P 〈 0.05）. The blood glucose for all the pa- tients with schizophrenia had no significant difference after 4 and 8 weeks treatment compared with before treatment. Conclusion： The four antipsychoties have signifieant effect on the body mass, but no significant effect on the blood glucose of patients with schizophrenia during acute short-course treatment.