他汀类药物的临床应用

Clinical Application of Statins

本文回顾总结了临床试验研究他汀类药物在降脂治疗中的作用,如对缺血性心脏病患病率和死亡率的一级预防,对冠心病相关事件的二级预防等,证实他汀类药物可降低胆固醇,减少冠心病事件的危险性。详细介绍了如何合理应用他汀类药物,包括适应症、药物选择、联合用药、非药物治疗、辅助药物治疗等;提出用药物期间安全性检测指标和不良反应监测;最后对他汀类药物进行药效评价和展望。

This paper summarizes the effect of statins in lowering blood lipid through clinical experimental research retrospectively,for example,the primary prevention on morbidity rate and mortality rate of ischemic heart disease and the secondary prevention of coronary heart disease-related events and the like.It confirms that statins can lower cholesterol and reduce the risk of coronary heart disease events.This paper introduces how to use statins rationally in detail,including indication,drug selection,drug combination,non-drug treatment and auxiliary drug treatment.It proposes indexes used to test safety and monitor adverse reactions during medication;it evaluates the effect of statins and provides an outlook in the end.