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丙酮酸对多脏器及组织损伤保护作用的研究进展 被引量:4

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摘要 丙酮酸是三羧酸循环的中间产物、糖酵解途径的终产物,或在细胞浆中转变成乳酸供能,或进入线粒体内,氧化脱羧生成乙酰辅酶A,进入三羧酸循环被氧化成CO2和H2O,释放能量.丙酮酸在体内是三大营养物质相互转化的重要枢纽,可通过三羧酸循环和辅酶A(CoA)进行脂肪、氨基酸和糖之间的转化.丙酮酸主要有抑制细胞凋亡、抗氧化、抗酸、抗炎等生理作用[1].
作者 刘维维 胡森
出处 《感染.炎症.修复》 2012年第3期187-189,共3页 Infection Inflammation Repair
基金 军队"十一五"专项课题基金(062055)
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  • 1Flaherty DC, Hoxha B,Sun J et al. Pyruvate-fortified fluid resus-citation improves hemodynamic stability while suppressing sys- temic inflammation and myocardial oxidative stress after hemor- rhagic shock. Mil Med,2010,175(3) : 166-172.
  • 2Hermann HP, Pieske B, Schwarzmtiller E, et al. Haemodynamic effects of intracoronary pyruvate in patients with congestive heart failure. Lancet,1999,353(9161) :1321-1323.
  • 3Sharma P,Walsh KT,Kerr-Knott KA,et al. Pyruvate modulates hepatic mitochondrial functions and reduces apoptosis indicators during hemorrhagic shock in rats. Anesthesiology, 2005,103 (1) : 65-73.
  • 4Sharma AB, Barlow MA, Yang SH, et al. Pyruvate enhances neurological recovery following cardiopulmonary arrest and re- suscitation. Resuscitation, 2008,76 : 108-119.
  • 5Ryou G,Ran Liu,Ren M,et al. Pyruvate protects the brain a- gainst ischemia-reperfusion injury by activating the erythropoie- tin signaling pathway. Stroke,2012,43(4) : 1101-1107.
  • 6郝志强,王为忠,李孟彬,张洪伟.丙酮酸作用下大鼠移植小肠缺血再灌注损伤中核转录因子的变化[J].中国组织工程研究与临床康复,2008,12(18):3406-3409. 被引量:4
  • 7Devin C, Flaherty I3(2, Hoxha B, et al. Pyruvate-enriched resusci- tation protects hindlimb muscle from ischemia:reperfusion inju- ry. Mil Med,2010,175(12) : 1020-1026.
  • 8Gou D,Tan H,Cai H,et al. Pyruvate effects on red blood cells during in vitro cardiopulmonary bypass with dogs' blood. Artif Organs,2012-06-01[Epub ahead of print].
  • 9Yang H, Magilnick N, Xia M,et al. Effects of hepatocyte growth factor on glutathione synthesis,growth, and apoptosis is cell den- sity-dependent. Exp Cell Res, 2008,314 : 398-412.
  • 10Mayr JA,Freisinger P,Schlaehter K,etal. Thiamine pyrophos- phokinase deficiency in encephalopathic children with defects in the pyruvate oxidation pathway. Am J Hum Genet, 2011,89 (6) :806-812.

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