氧氟沙星三元配合物的光谱分析新方法研究及应用

The research and application of a new spectrophotometric method for ofloxacin ternary complex

以水-乙醇作为溶剂,在pH为5.8的磷酸二氢钾-氢氧化钠缓冲溶液中,氧氟沙星与茜素、稀土镧离子反应形成三元配合物体系.紫外吸收光谱研究结果表明:该三元配合物体系在295 nm处有最大吸收波长,表观摩尔吸收系数为3.60×104L.mol-1.cm-1.氧氟沙星在0.54～30.36 mg/L范围内符合朗伯-比尔定律,方法的检出限为0.02 mg/L.用于市售药品的含量分析,得回收率为93.9%～97.11%,相对标准偏差为0.65%～1.29%.

Lanthanum（ III ） ion is coordinated with ofloxacinand and alizarin to form a rare earth ternary complex with potassium dihydrogen phosphate - sodium hydroxide buffer solution （ pH = 5.8 ） in the solvent of ethanol. The absorption peak of the rare earth ternary complex is centered at 295 nm. Its apparent molar absorptivity at 295.0 nm is 3.60 x 104 Lomol - locm- 1. The linear range was 0.54 - 30.36 mgoL - 1 with a detection limit of 0. 012 mgoL - 1. It＇s a simple, rapid, and convenient method for the determination of the investigated drug in tablet.