4种肿瘤标志物检测在良恶性胸腔积液鉴别诊断中的应用

Application of four kinds of tumor markers in distinguishing pleural effusion

目的通过对胸腔积液中癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原199(CA199)、铁蛋白(SF)的检测,探讨4种肿瘤标志物在对伴胸腔积液的肺部良恶性肿瘤鉴别诊断中的价值。方法采用化学发光微粒子免疫测定法对54例肺癌患者和36例良性肺部疾病患者的胸腔积液进行CEA、CA125、CA199、SF测定。结果 4种肿瘤标志物在肺癌组中的含量均明显高于良性肺部疾病组,差异有统计学意义(P<0.05)。结论检测胸腔积液中CEA、CA125、CA199、SF对鉴别良恶性肺部疾病有重要价值,联合检测可提高辅助诊断的敏感性。

Objective To study the differential diagnostic value of combined determination of pleural effusion of CEA,CA125,CA199,SF,in patients with benign and malignant lung disease.Methods Pleural effusion concentrations of CEA,CA125,CA199,SF were measured by chemiluminescence immunoassay（CLIA） in 54 patients with malignant lung diseases and 3 patients with benign lung diseases.Results CEA,CA125,CA199 and SF concentrations were significantly higher in malignant pleural effusions comparing to non-malignant pleural effusions.Conclusion Detecting the concentrations of CEA,CA125,CA199 and SF of pleural effusion is helpful to differentiate benign and malignant lung diseases,which can greatly improve the diagnostic sensitivity for lung cancer.