石杉碱甲治疗阿尔茨海默病SOD、LPO浓度变化

The change of superoxide dismutase and lipoperoxide concentration in blood in patients with Alzheimer disease treated by huperxine

目的 :用石杉碱甲胶丸治疗阿尔茨海默病 ( AD) ,观察其红细胞和血浆内超氧化物歧化酶 ( SOD)、过氧化脂质 ( L PO)浓度变化与药物疗效之关系。 方法 :门诊患者 3 0例 ,每日服石杉碱甲胶丸共 2月 ,于疗前、疗后 1月、 2月分别测定认知功能水平及红细胞和血浆内 SOD、 L PO浓度。 结果 :该药有效率达 63.33 % ,能一定程度的改善记忆障碍和痴呆症状 ,治疗 1、 2个月后 ,红细胞和血浆内 SOD、 L PO浓度都较疗前有明显改善 ( P<0 .0 0 1) ,并与药物疗效和病程之间无明显关系 ( P>0 .0 5)。 结论 :SOD和 L PO可作为石杉碱甲胶丸治疗中的观察指标 ,但与疗效缺乏直接关系 ,推测 AD与 SOD和 L

Objective:To study the relationship between Superoxide dismutase (SOD) and Lipoperoxide (LPO) concentration in red cell and plasma and the therapeutic efficacy of huperzine A in the treatment of Alzheimer disease (AD). Method:Thirty outpatients had been treated by huperzine A for 2 months,and their cognitive function,SOD and LPO concentration were tested before and after treatment. Results:The efficacy of huperzine A was up to 63 33%.It could relieve memory disorder and dementia of patients to some degree.There was significant difference in SOD and LPO concentration in red cell and plasma before and after treatment( P <0 001).There was no significant association between SOD,LPO concentration and drug efficacy,disease course( P >0 05). Conclusion:SOD and LPO concentration can be as a mark in AD patients treated by huperzine A,but it has no direct relationship with the efficacy.It is possible that there is complicate correlation between AD and SOD,LPO.