艾司西酞普兰与舍曲林治疗老年躯体疾病伴发抑郁的疗效分析

A research of the curative effect of Escitalopram and Sertraline for the physical diseases associated with depression in elderly

目的:探讨艾司西酞普兰治疗老年躯体疾病伴发抑郁的疗效及安全性。方法:对2009年1月～2011年1月在我科住院的49例老年躯体疾病伴发抑郁患者随机分为艾司西酞普兰组与舍曲林组,为期六周,采用HAMD、CGI量表评定临床效果,以TESS评定不良反应。结果:共49例(艾司西酞普兰25例,舍曲林组24例),艾司西酞普兰组与舍曲林组的显效率分别为65.1%和67.4%,无显著差异,治疗一周后,艾司西酞普兰组HAMD减分率优于舍曲林组,治疗二周后无显著差异。艾司西酞普兰组副反应的发生率为28.0%,低于舍曲林组的37.5%。结论:艾司西酞普兰是一种疗效好,安全性高,起效快的治疗老年躯体疾病伴发抑郁的药物。

Objective To study the safety and efficacy of Escitalopram to treat physical diseases associated with depression in elderly. Methods 49 cases of physical diseases associated with depression in elderly in my hospital from January 2009 to January 2011 were randomly divided into Escitalopram group and Sertraline group. AIi patients were treated for six weeks, and the HAMD, CGI scale were used to assess the clinical effect, the TESS was used to evaluation the adverse reactions. Results The significant efficiency of all patients （Escitalopram group 25 cases, Sertraline group 24 cases） were 65.1% and 67.4% respectively, and there was no significant difference in two groups, after one week treatment, the reduced rate of HAMD in Escitalopram group better than Sertraline group; after two weeks treatment, there was no significant differences in two groups. The incidence of side effects in Escitalopram group was 28.0%, less than the Sertraline group, which was 37.5%. Conclusion Escitalopram is a good curative effect, high safety, work fast drug to treat the physical diseases associated with depression in elderly.