阻塞性睡眠呼吸暂停综合征与冠心病关系的随访研究

Investigation Follow-up Obstructive Sleep Apnea Syndrome and Coronary Heart Disease of the Relationship

目的:调查阻塞性睡眠呼吸暂停综合征(OSAS)与冠心病的关系。方法:1989年11月至2009年11月,通过对所属3市共13所军队和地方离退休干部休养所及部分地方人员共1868例进行OSAS与CHD关系的随访研究,采用家访式调查,每年进行1次体检,检查血压、血脂、血糖、心电图及X线胸片等,以发现存在冠心病表现时作为随访终点,随访时间为20年。结果:本组1868例被调查者中男956例,女912例,年龄53～82岁,平均年龄(63±6)岁。其中确诊OSAS者598(32.0%)例,无OSAS者1270(68.0%)例(对照组)。随访终点冠心病OSAS组337(56.4%)例、对照组315(24.8%,P<0.01)例。结论:长期随访显示,OSAS患者发生冠心病的可能性较一般人群高,考虑OSAS与发生冠心病存在相关性。20年随访提示OSAS可能是导致冠心病的独立危险因素。

bjective Investigation follow-up obstructive sleep apnea syndrome （OSAS） and coronary heart disease of the relationship. Methods In November 1989 to November 2009 1868 cases of prospective follow-up crowd, through the family visit type survey, the follow-up period 1 year medical examination, check the blood pressure, blood fat, sugar, electrocardiogram and X-ray chest radiograph, found coronary heart disease performance for follow-up end point, followed up for 20 years. Results Among the 1868 cases of 956 cases of male, female in 912 cases, age range, 53 to 82 years, average age 63 ＋ 6 years old. The diagnosis of OSAS 598 （32.0%） patients, 1270 （68.0%） were no OSAS （control group）. Conclusions The long-term follow-up, in patients with coronary disease OSAS effort likely more average crowd high, consider OSAS and the correlation between coronary disease. 20 years of follow-up tip SAS may be independent risk factors for coronary heart disease.