辛伐他汀对动脉粥样硬化性脑梗塞患者血清脂联素、TNF-a和内脂素的影响

The effect of Simvastatin on Adiponectin,Tumor Necrosis Factor-α and Visfatin in Patients with Atherosclerotic Cerebral Infarction

目的:探讨辛伐他汀对动脉粥样硬化性脑梗塞患者血清脂联素、内脂素及肿瘤坏死因子-a的影响。方法:87例动脉粥样硬化性脑梗塞患者随机分为实验组44例和对照组43例,对照组采用常规治疗,实验组在常规治疗的基础上加用辛伐他汀,共治疗14天。同时40例健康体检者作为健康组。治疗前后采用放射免疫分析法测定两组血清脂联素、内脂素及肿瘤坏死因子-a水平。检测结果采用t检验。结果:①动脉粥样硬化性脑梗塞患者APN水平低于健康组(P<0.05),治疗后辛伐他汀实验组APN显著升高,显著高于对照组(P<0.05);②动脉粥样硬化性脑梗塞患者TNF-α、内脂素水平均高于健康组(P<0.05),治疗后辛伐他汀实验组TNF-α、内脂素显著降低,显著低于对照组(P<0.05)。结论:辛伐他汀可能通过促进APN分泌,抑制TNF-α、内脂素分泌改善动脉粥样硬化。

Objective To explore the effect of simvastatin on adiponectin （APN）,tumor necrosis factor -α （TNF -α）in patients with atherosclerotic cerebral infarction（ACI）.Methods 87 patients with atherosclerotic cerebral were devided randomly divided into 2groups, 44cases as experimental group were treated by Conventional Treatment and simvastatin added and 43cases as control group were treated by Conventional Treatment.All patients were treated for 14d.40 healthy subjects served as normal controls. APN,TNF -α and visfatin in serum were detected by Radioimmunoassay before and after the clinical therapy. The results were analysed with t-test. Results （1）APN in the patients with ACI were significantly lower than that in healthy subjects （P〈0.05）. APN increased significantly in experimental group and were higher than that in control group （P〈0.05）. （2）TNF -α and visfatin in the patients with ACI were signifi- cantly higher than that in healthy subjects （P〈0.05）. APN decreased significantly in experimental group and were lower than that in control group （P〈0.05）. Conclusion Simvastatinmaybe improved Atherosclerotic by promoting APN and reducing TNF -α and visfatin.