孕妇血清人绒毛膜促性腺激素与妊娠期高血压疾病相关性的研究

Maternal serum human chorionic gonadotropin and gestational hypertension disease correlation studies

目的:探讨孕妇血清人绒毛膜促性腺激素(HCG)与妊娠期高血压疾病(HDCP)的相关性。方法:采用前瞻性对照分析的方法,研究门诊定期产检的600名孕妇,根据临床表现分为正常妊娠组和妊娠期高血压组,于不同妊娠时期测定血β-HCG的变化并加以分析。结果:①正常妊娠孕妇妊娠8～12周血β-HCG明显升高,孕中晚期则维持在较低水平(P<0.01);②HDCP患者妊娠中晚期血β-HCG较正常妊娠孕妇明显升高(P<0.01),子痫前期组血β-HCG值又高于妊娠期高血压组(P<0.05);③妊娠28～36周是HDCP的高发孕周,且易发展为子痫。结论:血β-HCG可以作为临床预测HDCP发生的有效检测指标。

Objective To investigate the maternal serum human chorionic gonadotropin （ HCG ） and pregnancy induced hypertension （HDCP） correlation. Methods Using a prospective comparison analytic method, the study of outpatient regular production seized in 600 pregnant women, according to the clinical manifestations were divided into the normal pregnancy group and the gestational hypertensive group, in different gestational age determination of bloodβ -HCG changes and analysiso Results （1）8-12 weeks of gestation in normal pregnant women blood β-HCG increased significantly, during the second trimester of pregnancy is maintained at low levels （ P〈0.01）;（2） HDCP patients in late pregnancy serum β-HCG was significantly higher than in normal pregnancy （P〈0.01）, pre-eclampsia group blood β -HCG value was higher than thai of gestational high blood pressure group （ P〈0.05）; （3）gravid 28-36 week is HDCP high gestational week, and easy development Of preeclampsiao Conclusion The blood β -HCG can be used as a clinical predictors of HDCP to effectively detect index.