2-芳基-α-烷氧基咪唑〔1,2-α〕并吡啶-3-乙酰胺类化合物的合成及其催眠活性

Studies on the Synthesis and Hypnotic Activity of Derivatives of 2-Aralkyl-α-alkyloxide imidazo〔1,2 -α〕pyridine-3-acetylamine

选择超短时作用型镇静催眠药zolpidem作为先导化合物 ,设计合成了 8个 2 芳基 α 烷氧基咪唑〔1,2 α〕并吡啶 3 乙酰胺类目标物 ,所有化合物均未见文献报道 .药理初筛结果表明 :目标化合物对小鼠有镇静作用 。

On the basis of structural analysis,zolpidem,a hypnotic and sedative,was selected as a lead compound.Eight derivatives of 2 aralkyl α alkyloxide imidazo〔1,2 α〕pyridine 3 acetylamine were designed and synthesized.All of them had never been reported in literature.Preliminary pharmacological tests showed that the target compounds possessed certain hypnotic activity on mice.