1、6二磷酸果糖治疗新生儿缺氧缺血性脑病疗效观察及预后探讨

CLININCAL EFFICACY AND PROGNOSIS OF FRUCTOSE 1.6 DIPHOSPHATE IN NEONATAL HYPOXIC ISCHAEMIC ENCEPHALOPHATHY

探讨 1、6二磷酸果糖 (FDP)治疗新生儿缺氧缺血性脑病 (HIE)的疗效及预后。应用 FDP治疗了 5 2例 HIE患儿 ,剂量 2 5 0 mg/ kg/ d,半小时内静脉滴入 ,每日1次 ,7天 1疗程 ,轻者用 1疗程 ,重者用 2疗程。结果表明 :临床疗效治疗组有效率48/ 5 2 (92 .3% ) ,对照组有效率 30 / 40 (75 % ) ,两组有显著性差异 P <0 .0 5。患儿满 30天查脑电图及头颅 CT复查 ,治疗组异常率分别为 10 / 5 0 (2 0 % ) ,6 / 5 0(12 % ) ;对照组分别为 16 / 37(4 3.2 % ) ,10 / 37(2 7% ) ,两组均有显著性差异 P <0 .0 5。随防 6～ 36月 ,两组后遗症发生率分别为 4/ 35 (11.4% )、9/ 30 (30 % ) ,有显著性差异 (P <0 .0 5 )结论 :外源性 FDP能显著改善 HIE患儿临床症状、脑电图及头颅CT的恢复 ,改善预后 。

To investigate the clinical efficacy and prognosis of fructose 1 6 diphosphate (FDP)in the treatment of neonatal hypoxic ischaemic encephalophathy(HIE).52 neonatal with HIE aere given FDP 250mg/kg/d drip within half anhour,qd.Mild HIE patients were treated in this way for 7 days,severe patients for 14 days.Results showed the clinical effective rate was 92.3%(48/52)in treatment group and 75%(30/40) in control group.There was significantdifference between the two groups(p<0 05) Checked by EEG and brain CT after 30 days, abnonmal rates were 20%(10/50) and 12%(6/50) in treatment group,43 2%(16/37)and 27%(10/37) in control group respectively,which showed great difference between two groups(p<0.05).During th follow up survey period of 6 to 36 months,the sequel incidence rate was significantly lower in treatment group than that in control group with 11.4%(4/35)nad 30%(9/30) respectively(p<0.05).Thesrgose exogenous FDP can obviously improve clinical sympotoms and prognosis as well as decrease sequel incidence in neonate with HIE.(Original article in page 114)