TTV单独及重叠HBV感染的临床研究

Clinical Study on Transfusion Transmitted Virus (TTV) Single Infection and Superinfection with HBV

目的:了解输血传播病毒(Transfusion Transmitted Virus,TTV)单独及重叠乙肝病毒(HBV)感染的临床特征,探讨其致病性。方法:用套式聚合酶链反应检测血清中TTV DNA,用ELISA法和/或PCR法对其他肝炎病毒标志物进行血清学检测。结果:肝病患者TTV DNA总的阳性率为21.9%(107/489)。从临床分型来看,TTV单独感染者以急性肝炎(AH)为多见,占75%(12/16),明显高于重叠HBV感染者13%(2/15)(x^2=11.9,P<0.01),而重叠感染者以慢性肝炎(CH)居多,占67%(10/15),明显高于单独感染者19%(3/16)(x^2=7.3,P<0.01)。结论:TTV单独感染多表现为急性肝炎,重叠HBV感染时对病情的影响不明显,提示TTV具有一定的致病性。

Aim: In order to study the clinical stigma of TTV single infection and superinfection with HBV, and analyze its pathogenesis. Methods: TTV DNA in serum samples was detected by nested Polymerase Chain Reaction (PCR)t the markers of other hepatitis virus in serum were detected by ELISA and/or PCR. Results: TTV DNA was found in 21. 9% (107/489) of patients with liver disease. Acute hepatitis (AH) occured in TTV single infection patients 75% (12/16) more frequently than in superinfection with HBV13% (2/15) (x2 = 11.9, P<0. 01). Chronic hepatitis (CH) occured in superinfection with HBV patients 6 7% (10/15) more frequantly than in TTV single infection patients 19% (3/16) (x2 = 7. 3, P<0. 01). Conclusion: Most of TTV single infection patients displayed as acute hepatitis, the state of illness had no obvious changes when TTV superinfected with HBV. The results suggest that TTV might have pathogenesis.