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Emerging issues in peripheral nerve repair

Emerging issues in peripheral nerve repair
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摘要 It is today widely acknowledged that nerve repair is now more than a matter of perfect microsurgical reconstruction only and that, to further improve clinical outcome, the involvement of different scientific disciplines is required. This evolving reconstructive/regenerative approach is based on the interdisciplinary and integrated pillars of tissue engineering such as reconstructive microsurgery, transplantation and biomaterials. In this paper, some of the most promising innovations for the tissue engineering of nerves, emerging from basic science investigation, are critically overviewed with special focus on those approaches that appear today to be more suitable for clinical translation. It is today widely acknowledged that nerve repair is now more than a matter of perfect microsurgical reconstruction only and that, to further improve clinical outcome, the involvement of different scientific disciplines is required. This evolving reconstructive/regenerative approach is based on the interdisciplinary and integrated pillars of tissue engineering such as reconstructive microsurgery, transplantation and biomaterials. In this paper, some of the most promising innovations for the tissue engineering of nerves, emerging from basic science investigation, are critically overviewed with special focus on those approaches that appear today to be more suitable for clinical translation.
作者 Stefano Geuna Pierluigi Tos Bruno Battiston
机构地区 Neuroscience Institute of the "Cavalieri Ottolenghi" Foundation (NICO) & Department of Clinical and Biological Sciences Department of Traumatology
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第29期2267-2272,共6页 中国神经再生研究（英文版）
基金 supported by San Paolo Bank Foundation and Piemonte Region
关键词 nerve reconstruction tissue engineering cell and tissue transplantation gene therapy BIOMATERIALS peripheral nervous system MICROSURGERY artificial hollow tubes muscle-vein-combined tubes non-nervous guides neural regeneration nerve reconstruction tissue engineering cell and tissue transplantation gene therapy biomaterials peripheral nervous system microsurgery artificial hollow tubes muscle-vein-combined tubes non-nervous guides neural regeneration
分类号 R745 [医药卫生—神经病学与精神病学]
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  • 2Geuna S, Fornaro M, Raimondo S, et al. Plasticity and regeneration in the peripheral nervous system. Ital J Anat Embryol. 2010;115:91-94.
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Neural Regeneration Research
2012年 第29期

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