伪麻黄碱水杨酸盐的药用研究

Study on medical uses of pseudoephedrine salicyate

目的 :研究伪麻黄碱水杨酸盐的解热作用及其对心率、血压以及对组胺致敏豚鼠刺激反应的影响。方法 :用肌注和口服两种方法考察伪麻黄碱水杨酸盐的解热作用 ;用静注的方法考察其对动物心率和血压的影响 ;用组胺致敏引起豚鼠喷嚏和抓鼻现象的抑制情况来验证其抗过敏效果。结果 :肌注 1h开始使发热兔体温下降 ,维持 3～ 4h ,口服效果与阿司匹林接近 ;在剂量范围内对动物的心率和血压无明显影响 ;可减轻组胺引起的豚鼠刺激性喷嚏反应。结论 :伪麻黄碱水杨酸盐的解热镇痛作用好于阿司匹林 ,不良反应少 。

Objectives:To study the antipyretic effect of pseudoephedrine salicylate and its effects on heart rate(HR),blood pressure (BP),and response to allergic reaction in guinea pigs induced by histamine.Methods:In study of the antipyretic effect,2 route of administration i.m and p.o were adopted.In study its effects on HR and BP,intravenous injection was adpted,the response to sneezing and scraching nose of guinea pigs induced by histamine was used to validate its antiallergic effects.Results:After 1h of intremuscular injection of pseodoepherine salcylate,the temperature of rabbit dropped significantly in comparison with saline and maitained for 3h.Its antipyretic effect was equal to asprin when it was given orally.No obvious effects on HR and BP were observed,but the aneezing in guinea pigs induced by histamine can be relieved by pseudoephedrine salcylate.Conclusion:The antipyretic effect of pseudoephedrine salicylate is better than that of Aspirin.No ADRs were observed.