男性不育症患者503例染色体分析

Chromosomal analysis of 503 cases male patients with infertility

目的探讨染色体异常与男性不育患者之间的关系。方法选取503例男性不育症患者,采用外周血淋巴细胞培养,常规染色体G显带核型检测与分析。结果 503例男性不育症患者中无精子症156例,染色体异常18例,异常率为11.54%,其中性染色体异常15例,常染色体异常3例;少精子症347例,染色体异常13例,异常率为3.75%,其中性染色体异常4例,常染色体异常9例,无精症组与少精症组染色体异常差异有统计学意义(P<0.05)。503例男性不育症患者中染色体异常31例,异常率为6.16%,31例异常染色体中涉及8、9、10、13、14、15、17、18、21、Y等染色体。结论染色体异常是导致男性不育的遗传因素之一,对男性不育患者应常规行染色体检查,有助于病因的诊断。

Objective To study the relationship between the abnormal chromosome and the infertile men.Methods 503 cases of male patients with infertility were selected,and peripheral blood lymphocyte culture and conventional karyotype detection and analysis by G-banding was conducted.Results In 503 cases of infertile men,the number of patients with azoospermia were 156,abnormal chromosomes were 18,the abnormal rate was 11.54%,the number of sex chromosomes and autosomal abnormalities were 15 and 3;the number of patients with oligozoospermia were 347,abnormal chromosome were 13,the abnormal rate was 3.75%,the number of sex chromosomes and autosomal abnormalities were 4 and 9.There were significant differences about chromosomal abnormalities between azoospermia group and oligozoospermia group.The chromosomal karyotypes of 31 cases infertile men were abnormal in 503,the abnormal rate was 6.16%,chromosome abnormalities were comprised of the 8th,9th,10th,13ird,14th,15th,17th,18th,21st and Y chromosome among 31 cases.Conclusion Chromosomal abnormality is one of the genetic factors leading to infertile men,it was recommended that in fertile men take routine cytogenetic analysis,contributing to diagnose the cause of the disease.