早期碱剩余对感染性休克患者的病情严重程度预测价值

e Value of Early Base Excess in Predicting the Severity of Septic Shock

目的探讨早期碱剩余对感染性休克患者病情严重程度的预测价值。方法对2009年2月-2011年2月资料完整入院的感染性休克患者60例进行回顾性分析,按死亡及存活进行分组,对最初24 h的碱剩余值差异及血乳酸清除率情况进行对照研究。结果死亡组碱剩余值变化及乳酸清除率低于存活组(P<0.05)。治疗后碱剩余≤6 mmol/L较碱剩余>6 mmol/L的患者病死率明显增加,尤其是治疗后24 h碱剩余仍≤6 mmol/L病死率高达92.23%。结论早期碱剩余有助于感染性休克预后评估和指导临床治疗。

Objective To investigate the value of early base excess in predicting the severity of septic shock. Methods We retrospectively analyzed the complete clinical data of 60 patients with septic shock treated in our hospital between February 2009 and February 2011. The patients were divided into the death and survival groups. Base excess value difference and blood lactate clearance rate in the first 24 hours were compared in the case-control study. Results The death group had significantly lower base excess value changes and lactate clearance rate than the survival group （P 〈 0.05）. After treatment, patients with base excess lower or equal to -6 mmol/L had a higher death rate than those with base excess value higher than 6 mmol/L. Especially, after 24 hours of treatment, those with their base excess value still lower or equal to -6 mmol/L had a mortality up to 92.23%. Conclusion Early base excess is helpful in assessing the prognosis of septic shock and in guiding its clinical treatment.