三苯氧胺配伍米索前列醇终止早孕的初步临床观察

A pilot study of Tamoxifen with Misoprostol for Termination of Early Pregnancy.

目的:探索三苯氧胺配伍米索前列醇终止早孕的可能性。方法:给84例停经≤49天孕妇服用不同剂量三苯氧胺进行临床预试验。两组分次服80mg和160mg三苯氧胺,然后阴道用80μg米索前列醇。结果:①160mg三苯氧胺和米索前列醇联合应用成功率为90％。其出血天数为8～9天,未见副作用。②160mg三苯氧胺组的完全流产率高于80mg三苯氧胺组。结论:三苯氧胺合并阴道用米索前列醇能够有效终止早孕,其方法有待进一步探索。

The purpose of the study was undertaken to determine whether tamoxifen followed by misopros-tol would be an effective medical method of elective termination of early pregnancy. The method is as follows : 84 early pregnant women with amenorrhea ≥49 days were divided into 2 groups. Group l(n = 35) : tamoxifen 80mg(20mg qd) was given in four days, group 2 (n = 49): tamoxifen 160mg (20mg bid) was given in four days. Misoprostol 800μg by intraviginal placement on the 5th day, If abortion did not occur within the next 24h, A second dose of 800μg of misoprostol was given. The results showed that the compele abortion rate of each group was 74. 3% and 89. 8%, respectively, the mean duration of uterine bleeding was 8 - 9days (range 2-21days) , the side effects were low. Conclusion: ingestion of tamoxifen followed by intrav-aginal misoprostol may be an effective method of elective termination of early pregnancy.