三分三浸膏片与消旋山莨菪碱片的药效对比实验研究

Experimental Comparative Study on the Efficacy of Scopoloa Acutangula Extract Tablets and Racanisodamine Tablets

目的对三分三浸膏片与消旋山莨菪碱片进行药效对比实验研究,观察三分三浸膏片与消旋山莨菪碱片的药效差异,为三分三浸膏片的临床应用提供实验依据。方法通过镇痛、抗感染、抗溃疡、镇咳实验,观察三分三浸膏片与消旋山莨菪碱片的镇痛、抗感染、抗溃疡及止咳作用。结果三分三浸膏片两个剂量组及消旋山莨菪碱片两个剂量组能明显抑制小鼠的痛反应,能明显抑制小鼠的炎症反应,能明显抑制无水乙醇引发的胃溃疡,能明显抑制氨水引发的咳嗽,与空白组相比,有显著性差异(P<0.01或P<0.05)。结论三分三浸膏片与消旋山莨菪碱片具有明显的镇痛、抗感染、抗溃疡及镇咳作用;其中,三分三浸膏片的药效优于等剂量的消旋山莨菪碱片。

Objective To observe the efficacy differences of the Scopoloa acutangula extract tablets and Racanisodamine tablets,and provide the experimental basis for Clinical application of Scopoloa acutangula extract tablets.Methods To observe the analgesic,anti-inflammatory,anti-ulcer and cough effects of the Scopoloa acutangula extract tablets and Racanisodamine tablets by the analgesic,anti-inflammatory,antiulcer,antitussive experiments.Results The Scopoloa acutangula extract tablets and Racanisodamine tablets could significantly inhibit the pain response,the inflammatory response,ethanol-induced gastric ulcer and ammonia-induced cough in mice,compared with the control group,there were significant differences（P0.01 or P0.05）.Conclusion The Scopoloa acutangula extract tablets and Racanisodamine tablets have significant analgesic,anti-inflammatory,anti-ulcer and antitussive effects,and the efficacy of Scopoloa acutangula extract tablets are superior to the Racanisodamine tablets.