多巴胺与纳洛酮治疗新生儿缺氧缺血性脑病84例疗效探讨

84 Cases Efficacy of Dopamine and Naloxone Treatment of Neonatal Hypoxic-ischemic Encephalopathy

目的探讨多巴胺联合纳洛酮治疗新生儿缺氧缺血性脑病的临床治疗效果。方法选择84例2009年4月至2012年4月期间我院收治确诊为新生儿缺氧缺血性脑病的患儿随机分为观察组和对照组,两组患儿均采用常规对症支持治疗,其中观察组患儿加用多巴胺10μg/(kg min),纳洛酮0.07μg/(kg min),输液泵持续静脉滴注,比较两组患儿治疗效果及不良反应。结果观察组患儿恢复意识、正常反射功能和肌张力的时间明显短于对照组患儿(P<0.05),两组患儿均未出现不良反应。结论在常规治疗HIE的基础上加用多巴胺联合纳洛酮治疗效果更佳,且安全性较好,值得临床推广。

Objective To investigate the efficacy of neonatal hypoxic-ischemic encephalopathy treatment with dopamine and naloxone.Methods 84 cases of HIE children were treated in our hospital during April 2011~2012,and they were divided into observe group and control group randomly.General symptomatic and supportive treatment was used in both groups,while dopamine 10μg/（kg min） and naloxone 0.07μg/（kg min） used in observe group,continuous intravenous infusion by infusion pump.Efficacy and side effects were compared between the two groups.Results The time of consciousness,normal reflection and muscle tension regained was shorter in observe group than that in control group（P 0.05）.No side effects were found in both groups.Conclusion Dopamine and naloxone added to HIE conventional treatment could make the efficacy better and safer.It was worthy of clinical.