运动状态下白细胞介素6介导骨保护素相关因子信号通路对骨代谢的调节

Effect of osteoprotegerin and its relevant factor signal pathway on interleukin-6 mediated bone metabolism at moving state

背景:骨保护素-核因子κB受体活化因子配体-核因子κB受体活化因子信号通路是调节骨代谢的经典通路,白细胞介素6和该信号通路存在相关性,运动对骨代谢的影响机制与二者的调节作用密切相关。目的:研究运动状态下白细胞介素6介导骨保护素-核因子κB受体活化因子配体-核因子κB受体活化因子信号通路对骨代谢活动的调节,揭示运动状态下此信号通路的内在联系。方法:检索CNKI、EBSCO和Elsevier数据库中有关运动应激、白细胞介素6、骨保护素-核因子κB受体活化因子配体-核因子κB受体活化因子信号通路的论文,选取其中39篇具有代表性和最新研究进展的论文为参考文献进行分析整合,揭示运动、白细胞介素6及信号通路之间的关系。结果与结论:目前研究表明白细胞介素6和骨保护素-核因子κB受体活化因子配体-核因子κB受体活化因子信号通路在骨代谢过程中密切相关,在不同运动负荷和强度状态下白细胞介素6和该信号通路的表达,呈现出特异性的运动应激的反应与适应。研究结果不仅有助于揭示运动健骨机制,而且可应用于骨关节病的预防与治疗领域。

BACKGROUND：Osteoprotegerin-receptor activator of nuclear factor-κB ligand-receptor activator of nuclear factor-κB （OPG/RANKL/RANK） signal pathway is a classic signaling pathway for bone metabolism. Interleukin-6 （IL-6） has a correlation with the OPG/RANKL/RANK signal pathway. The effect of exercise on bone metabolism is highly related with the modulation of the two above. OBJECTIVE：To research the modulation of OPG/RANKL/RANK signal pathway on bone metabolism under the inducement of IL-6 at moving state and to find the inherent relationship between IL-6 and OPG/RANKL/RANK signal pathway. METHODS：CNKI, EBSCO and Elsevier databases were retrieved by computer for papers concerning exercise stress, IL-6, and OPG/RANKL/RANK . Thirty-nine representative and updated papers were chosen and analyzed to reveal the relationship among exercise, IL-6 and OPG/RANKL/RANK signal pathway. RESULTS AND CONCLUSION：These analyses suggested that there is high correlation between IL-6 and OPG/RANKL/RANK in the process of bone metabolism. The expressions of IL-6 and OPG/RANKL/RANK signal pathway at different exercise intension and load have specific exercise stress response and adaption .These osteoarthrosis findings could not only help to reveal the mechanism of exercise for bone health, but also be applied to prevent and treat osteoarthrosis.