颌骨牵张成骨动物模型的研究与应用

An animal model of maxillofacial distraction osteogenesis

背景:动物模型的建立是颌骨牵张成骨研究的重要组成部分。目的:回顾颌骨牵张成骨动物模型建立的研究进展。方法:检索2000/2011PubMed数据库、SCI数据库、维普数据库及万方数据库,中文检索词为"牵张成骨、下颌骨、上颌骨、颅颌面",英文检索词为"Distraction Osteogenesis、mandibular、maxillary、craniofacia"。从颌骨牵张成骨动物模型的建立方法,实验动物的选择及应用两方面对28篇文章进行总结。结果与结论:选择实验所用动物时应尽量选用与人体结构、功能、代谢及疾病特征相似的动物;选择标准化、解剖、生理特点与实验目的要求相符的动物。在牵张成骨的过程中还需结合所选动物的生长特点以及研究目的等确定术式,牵张间歇期,牵张速度以及固定期等关键因素。

BACKGROUND：The animal model establishment is an important part for the research of maxillofacial distraction osteogenesis. OBJECTIVE：To review the research process of the establishment of maxillofacial distraction osteogenesis animal model. METHODS：All the literatures were searched in the PubMed database, SCI database, VIP database and Wanfang database （2000/2001） with the Keywords of ＂distraction osteogenesis, mandibular, maxillary, craniofacial＂ in English or Chinese. A total of 28 articles were collected and analyzed in the aspects of the establishment of maxillofacial distraction osteogenesis animal model, and experimental animal selection and application. RESULTS AND CONCLUSION：The animals selected for the experiment should be similar to human in the aspects of structure, function, metabolism and disease characteristics. Standardized, anatomical and physiological characteristics animals that consistent with the requirements of experimental purposes were selected. The growth characteristics of the selected animals and research purposes in the process of distraction osteogenesis, as well as the stretch-rate and fixed term in the intermission of distraction should be considered.