促红细胞生成素促进组织器官血管新生的理论研究与应用

Theoretical research and application of erythropoietin to promote angiogenesis of many tissues and organs

背景:促红细胞生成素自1906年发现至今,在大量组织器官中发现其不仅具有促进红细胞增殖、分化作用,而且阻止细胞凋亡,促进胶原、血管形成。目的:分析总结促红细胞生成激素在部分组织器官中促进血管新生方面的研究,以阐明其在各专业的研究现状。方法:分别以"促红细胞生成激素,血管新生"和"Erythropoietin,angiogenesis"为关键词进行检索,CNKI数据库的检索时限为2005/2011,PubMed数据库的检索时限为1988/2011,西文生物医学期刊文献数据库的检索时限为2000/2011,检索内容为促红细胞生成激素在组织器官中促进血管新生的研究。保留符合纳入标准的33篇文献进行总结。结果与结论:促红细胞生成素是一种主要由成人肾脏和胚胎肝脏分泌的糖蛋白激素,其在心血管系统、脑组织、视网膜、子宫、肿瘤组织及皮肤等组织器官中,具有促进促进血管内皮祖细胞增殖、进一步促进血管新生的作用,并已经部分应用于临床治疗。

BACKGROUND：From 1906 until now, erythropoietin has been found in lots of tissues and organs, which cannot only promote proliferation and differentiation of red blood cells, but also prevent cell apoptosis and accelerate the formation of collagen and blood vessels. OBJECTIVE：To review the research about erythropoietin promoting angiogenesis in many tissue and organs and to clarify the status of its effect on angiogenesis. METHODS：A computer search of CNKI database （2005/2011）, PubMed database （1988/2011） and FMJS database （2000/2011） was performed by the first author using ＂erythropoietin, angiogenesis＂ in Chinese and English as the Keywords, to retrieve articles about the effect of erythropoietin on angiogenesis. Finally, 33 articles were included in result analysis. RESULTS AND CONCLUSION：Totally 45 articles were obtained by the preliminary check, the titles and abstracts and partial contents were screened, and 33 literatures meeting the inclusion criteria were summarized. The findings show that erythropoietin is a glycoprotein hormone secreted by the adult kidney and liver embryos. Erythropoietin can promote proliferation of endothelial progenitor cells and angiogenesis of the cardiovascular system, brain tissue, retina, uterus, tumor tissue, skin and so on, and has applied to the part of clinical treatment.