米非司酮联合甲氨蝶呤治疗输卵管异位妊娠的临床研究

Clinical research on the effect of mifepristone combined with methotrexate treatment for tubal ectopic pregnancy

目的对比单独使用甲氨蝶呤与米非司酮联合甲氨蝶呤治疗输卵管异位妊娠的疗效。方法 2009年5月-2011年12月入院的240例患者,随机分为实验组和对照组,每组120例。对照组只进行甲氨蝶呤的注射治疗。20 mg/次肌肉注射,1次/d,治疗5 d。实验组为米非司酮和甲氨蝶呤联合治疗。米非司酮采取空腹口服的方式,100 mg/次,2次/d。甲氨蝶呤的使用方法同对照组。结果实验组有效117例(97.5%),平均治疗天数为(14.8±5.07)d;对照组有效109例(90.8%),平均治疗天数为(21.17±5.88)d。两组比较差异有统计学意义(P<0.05)。结论米非司酮联合甲氨蝶呤治疗输卵管异位妊娠疗效优于单用甲氨蝶呤。

Objective To compare the effect of methotrexate combined with mifepristone treatment for tubal ectopic pregnancy.Methods 240 cases of tubal ectopic pregnancy patients admitted to hospital from May 2009 to December 2011 were randomly divided into experimental group and control group,120 cases each group.The control group was only given methotrexate,20 mg each time,by intramuscular injection,once a day,lasting 5 d.Experimental group was given mifepristone combined with methotrexate therapy.Mifepristone was taken oral,100 mg each time,2 times a day.The use of methotrexate was the same as control group.Results The effective cases of experimental group were 117 cases（97.5%）,and its average treatment time was（14.8 ± 5.07）d;the effective cases of control group were 109 patients（90.8%）,and its average treatment time was（21.17 ± 5.88）d.There was significant difference between the two groups（P0.05）.Conclusion The efficacy of mifepristone combined with methotrexate treatment for tubal ectopic pregnancy is superior to methotrexate treatment only.