Hhcy对脑梗死氧化应激损伤机制的研究

THE ROLE OF HYPERHOMOCYSTINEMIA IN THE OXIDATIVE STRESS MECHANISM OF ISCHEMIC INJURY IN CEREBRAL INFARCTION

目的:研究血浆高同型半胱氨酸(Homocysteine,Hcy)水平致脑梗死氧化应激损伤可能的致病机制。方法:选取急性脑梗死患者,根据血浆总同型半胱氨酸(tHcy)水平,将其分为Hhcy组和非Hhcy(Nhhcy)组,除外脑血管疾病和肝肾甲状腺疾病患者40例作为对照。分别测血浆tHcy、血清丙二醛(MDA)、血浆超氧化物歧化酶(SOD)、血浆总抗氧化能力(total antiox-idant capacity,TAC)、谷胱甘肽过氧化物酶(GSH-XP)、氧化型谷胱甘肽(GSSG)水平,并研究其相关性。结果:病例组tHcy、MDA水平显著高于对照组(均P<0.01);病例组中Hhcy患者的tHcy、MDA、SOD、TAC、GSH-PX、GSSG水平显著高于Nhhcy(P<0.01)。tHcy水平与MDA、SOD、TAC、GSH-PX、GSSG水平具有相关性(P<0.01)。结论:Hhcy在脑梗死发病机制中的作用可能与其参与氧化应激反应损伤过程有关。

Objective：To explore the mechanism of cerebral infarction caused by hyperhomocystinemia.Methods： Eighty paitents with acute cerebral infarction were chosen for case group.According to their levels of Plasm total homocystine,they were divided into two groups：hyperhomooysdnemia group and nonhyperhomooysdnemia group.Forty patients without cerebrovascular disease,hepatophy,nephrosis and thyroid gland disease were chosen as control subjects.Plasm levels of total homocysteine,serum level of MDA、SOD、TAC、GSH-PX、GSSG were measured respectively.Their correhtions were also studied.Results： Plasma level of tHcy and serum levels of MDA、SOD、TAC、GSH-PX、GSSG significanty increased in case group in comparison with control subjects（P0.01）;Levels of tHcy,MDA、SOD、TAC、GSH-PX、GSSG in hyperhomocystinemia group were significanly higher than those of nonhyperhomooysdnemia group.Plasma levels were correlated with serum levels of MDA、SOD、TAC、GSH-PX、GSSG.Conclusion：Hyperhomocystinemia causes cerebral infarction possibly by oxidative stress injury.