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糖尿病视网膜病变患者黄斑水肿的抗血管内皮生长因子-A治疗

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摘要 糖尿病视网膜病变(DR)是糖尿病患者微血管病变的严重并发症之一。黄斑是眼底视网膜的主要功能区域,主司明视觉和色觉,糖尿病性黄斑病变包括黄斑水肿(DME)渗出、黄斑缺血及增殖性改变等。其中DME是导致糖尿病人群视力下降最常见的原因,是发达国家工龄阶层导致视力丧失的主要原因。DME会在DR的不同阶段发生,长期存在的黄斑水肿将导致黄斑囊样变性,视力损害严重且不可逆。随着近年糖尿病患者的增加,DME发病率也在不断升高,流行病学调查显示18岁以上糖尿病人群中为3%~6%,在DR人群中高达14%,我国相关调查显示DME患病率为16.22%,Ⅱ型糖尿病病程超过10年者DME可达到27.03%。
出处 《中华糖尿病杂志》 CAS 2012年第10期579-581,共3页 CHINESE JOURNAL OF DIABETES MELLITUS
基金 国家973课题(2011CB707506) 国家自然科学基金(81170861) 上海市重点基础研究项目(11JCl410600)
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