危重症患者尿白介素-18水平变化对疾病转归的影响

The influence of urinary interleukin 18 level changes on disease prognosis in critically ill patients

目的研究ICU危重症患者尿白介素-18(uIL-18)的变化对其在ICU的住院时间及疾病转归的影响。方法根据纳入标准选择ICU收治的危重症患者为研究对象,收集其入院2 h内的尿液标本。酶联免疫吸附法检测尿液标本中uIL-18含量,根据测量结果分为两组:A组(uIL-18﹥100 pg/ml)、B组(uIL-18≤100 pg/ml),观察各组ICU住院天数及疾病转归。结果 A组与B组患者的疾病转归有差异,且差异具有统计学意义,在ICU住院天数两组间差异无统计学意义。结论 ICU危重症患者尿uIL-18水平变化对疾病转归有影响。

Objective To study urinary interleukin - 18 （ulL - 18） changes in critically ill patients during their stay in ICU and the prognosis of the disease. Methods According to inclusion criteria in our hospital critically ill patients admitted to ICU for the study. Urine sam- pies of the patients were collected within 2 hours of their admission, ulL - 18 was detected by ELISA. According to ELISA results, the patients were divided into group A （ uIL - 18 〉 100 pg/ml） and group B （ uIL - 18 ≤ 100 pg/ml）. The length of stay in ICU and disease outcome in each group were observed. Results Disease outcomes were different between two groups, and the difference was statistically significant. However, there was no difference in the number of days hospitalized in the ICU between the two groups. Conclusion The change of uIL - 18 level may affect disease outcome in critically ill patients.