核受体对细胞色素P450的调控作用研究进展

Regulation of nuclear receptors on cytochrome P450 enzymes

核受体是一组配体依赖性转录因子超家族,与药物代谢过程中的基因表达调控密切相关,在机体的生长发育、新陈代谢、以及许多生理过程中发挥着重要作用,体内主要由组成型雄甾烷复体(CAR)、PXR、GR、AhR和PPAR几种核受体调控细胞色素P450基因表达介导药物代谢。本文综述了这几种核受体对细胞色素P450基因的调控作用,为药物-药物相互作用研究提供分子学机制。

Nuclear receptors are one superfamily of ligand-activated transcription factors and relate to regulating gene expression in drug metabolic processes.Nuclear receptors play an important role in growing development,metabolism and many physiological processes.Nuclear receptors including CAR,PXR,GR,AhR and PPAR mediate drug metabolism by regulating cytochrome P450 gene expression in vivo.This paper reviewed the regulation effect of several nuclear receptors on cytochrome P450 gene in order to provide molecular mechanism for drug interaction.